McCord and her staff work to extradite a Mexican cartel leader to a U.S. prison to diminish the opioid crisis; the cartel leader escapes and an urgent search is undertaken.
When a Russian dissident flees to the U.S. after contracting smallpox, McCord and retired U.N. Ambassador Kat Sandoval must work with Russian Foreign Minister Konstantin Avdonin to contain the outbreak.
The president and Elizabeth refuse to negotiate with terrorists for the release of a captured CIA agent; Henry disagrees with them; Elizabeth tries to support Stevie through a difficult time.
Elizabeth is determined to hold a human trafficking conference in Kyrgyzstan; Elizabeth and Henry worry about Alison when she keeps coming home from college.
Secretary of State McCord must negotiate an agreement to prevent a government shutdown; it is proving difficult to find a suitable replacement for the chief of staff position.
Elizabeth tries to find funding for an electrical grid in a Syrian refugee camp during an impending government shutdown.
While Elizabeth is in Libya to help negotiate an end to its civil war, a tragic accident with her chauffeured car embroils her in an urgent situation to secure medical care for a gravely wounded local girl.
Elizabeth is blamed in a "fake news" story for a diplomat's death; Dmitri returns to work with Henry.
Elizabeth heads to Brussels to seek NATO's support against Russia when it threatens to invade Bulgaria; Henry turns to a former operative for help; Elizabeth discovers information about her friend that makes her question his loyalty.
Elizabeth and President Dalton head to Rome for the G20 Conference; Henry is sent to Israel to intercept the doomsday cult's bio-weapon; Blake reveals a personal secret to his former colleagues.
Elizabeth and her team work to secure the release of an American journalist who is being held hostage in the Sudan.
The U.S. hunts for the person believed to be behind the smuggling case; Jay gets kidnapped in Nice, France; Henry suspects the doomsday cult is planning an attack in Israel; Jason dupes his parents into giving him money.
When warring rebel groups threaten Somali food relief efforts and kidnap an American aide, Elizabeth considers asking a notorious Russian arms dealer for help; Henry is taken off the VFF doomsday cult case.
Elizabeth enlists the help of a Hollywood star to sway the president of Kyrgyzstan to end human trafficking in his country; Henry finds the bomb that's being held by the doomsday cult.
A computer sting uncovers the possible mole in the CIA arms smuggling ring; Henry worries that the doomsday cult is drugging his embedded operative; Elizabeth and her staff come up with a plan for dealing with black rhino poaching in Namibia.
China threatens to back out of Elizabeth's landmark global climate treaty due to her meeting with the Dalai Lama; Henry worries about the safety of his undercover operative; Abby serves Jay a custody agreement for their daughter.
Datu Andrada, the unconventional new president of the Philippines, hits on Elizabeth during a meeting to discuss an Asia-Pacific territory treaty; Elizabeth asks Jay to look into Kevin Park's CIA connections; Henry's operative goes radio silent.
Elizabeth tries to reunite the son of the Colombian president and the daughter of the rebel leader, whose upcoming marriage is at the heart of an important peace deal; Henry prepares to send his operative under cover.
Elizabeth and Jay's peace treaty plans for Iran and Israel are jeopardized when an influential rabbi is killed; Elizabeth's name is floated for a Nobel Peace Prize; Daisy makes a connection with a new work colleague.
Elizabeth and her staff fly to Africa to offer development aid but find the Chinese arrived there first with competing offers; Henry is asked to help investigate a Christian cult member who may be tied to the Illinois coffee shop attack.
Elizabeth tries to avoid international controversy after the Mongolian government sends her a horse as a gift; Gov. Sam Evans threatens to bring a lawsuit against Ohio for putting President Dalton on the election ballot.
Elizabeth attempts to broker peace between Israel and Iran to avoid war; Russell suffers a heart attack.
Elizabeth tries to stop Israel from taking military action against the Iranians after Iran is suspected of nuclear activities; Russell wants congressman Jeff Pearson to support President Dalton in the House's election vote.
As President Dalton eagerly awaits voting results on Election Day, Elizabeth uncovers information that could put America's peace deal with Iran in jeopardy; Jason challenges his parents by supporting another candidate for president.
When Venezuela's president and his immediate successors die in an earthquake, Elizabeth must stop the late president's son from taking over, and she must negotiate the release of some international aid workers that he arrested.
Elizabeth learns that someone with ties to the Saudi government funded the terrorist bombing of an Illinois coffee shop; Matt declines to issue a statement when information comes out that he and the bomber are linked to the same mosque.
After a CIA operative is captured by French intelligence, Elizabeth tries to get the operative released while keeping a U.S. - France state dinner on schedule; Russell attempts to get some big donors behind Dalton's campaign again.
Elizabeth must respond to a memo from the Bureau of African Affairs that criticizes the Dalton administration's lack of attention to the upcoming election in Angola; Henry and Jose get closer to finding the stolen antiquities.
Elizabeth is in a stalemate with the Chinese foreign minister as she lobbies for the release of U.S. environmental activists; Henry thinks a former student of Elizabeth's is his family's cyber stalker; Dalton's visit to Vietnam stirs up war memories.
With Algeria on the brink of a civil war, Elizabeth negotiates a regime change; Henry discovers that religious antiquities are being destroyed in Algeria by Hizb al-Shahid; the McCord children get their own security detail.
After a storm destroys a naval base in Bahrain, Elizabeth advises President Dalton to reconsider his approach to climate change as well as his foreign policy; Jose Campos attempts to get Henry back into the DIA.
Elizabeth gets shocking news about a political operative and learns President Dalton may be considering replacing her with a new Secretary of State; Stevie and Jareth get engaged.
The United States debates whether to enact a mission to secure nuclear weapons that belong to the Pakistani government before it collapses; the Murphy Station pursues terrorist Jibral Disah.
Henry, Jane and Jose are sent on a dangerous mission when President Dalton gets word that the world's most dangerous terrorist is hiding in Islamabad.
In Elizabeth's first speech to the United Nations, she condemns the terrorist group Hizb-al- Shahid and discusses forming a coalition against them with the Russian foreign minister; the talk creates a conflict of interest between Elizabeth and Henry.
After a member of the inner circle of a terrorist organization falls ill with a deadly virus, Elizabeth attempts to use his weakness to secure the release of a group of schoolgirls that are being held captive.
A mysterious plane crash interrupts peace talks between India and Pakistan; Henry tries to get information from one of Disah's wives; Elizabeth undergoes a grueling interview.
While accompanying Alison on a college campus tour, Elizabeth is ambushed by a group protesting a Chilean mining operation; Henry, Jane and Jose Campos try to locate Jibral Disah's third wife, Hijriyyah.
Elizabeth has 20 minutes to decide if she should question a person claiming to know the location of the world's most-wanted terrorist; Stevie wants to introduce her boyfriend to her parents.
After a shocking event occurs on American soil, Elizabeth must answer President Dalton's questions about how it happened.
Elizabeth deals with extremely sensitive issues in Saudi Arabia as she oversees a mission to find those responsible for a uranium heist in Eastern Europe.
After Henry's father dies, painful and shocking family secrets are uncovered; Russell decides to keep significant information from Elizabeth's team.
When Elizabeth travels to Myanmar to sign a Pacific Rim trade agreement, she is met with resistance from the country's American ambassador; Nadine tries to repair her relationship with her son.
An unanticipated turn of events threaten to dissolve a peace deal with Russia; an emergency occurs on the International Space Station.
Elizabeth and President Dalton discover a secret that could impact Maria Ostrov's reputation; Dmitri wants to stop being a spy.
Henry shares information that causes Elizabeth to reconsider her theory that the Russians are responsible for the attack on Air Force One.
Elizabeth, Russell and Mike B. must oust Craig Sterling from his role as national security adviser without creating a scandal; the person who hacked Air Force One is identified.
With the president's support, Elizabeth hopes to make history by lifting the Cuban trade embargo; Alison and Henry bond while in Havana.
Elizabeth is determined to seek justice when an American aid worker is killed in Syria; Dmitri asks Henry for help saving Ivan.
Following President Ostrov's death, President Dalton and Elizaeth fear an impending power grab within the Russian government; Jay forms a plan to combat Russian propaganda.
When Elizabeth disagrees with the president's response to tension with Russia, she is pushed out of the inner circle; incriminating photos of Harrison and Stevie come to light.
The president's administration encounters hostility while dealing with the Russian government; Dmitri is kidnapped and interrogated about being a spy.
When a Department of State employee is kidnapped in Afghanistan, Elizabeth takes former Secretary of State Madeleine Albright's advice over the president's recommendation; Henry has a hard time persuading a student to spy for the U.S. government.
Elizabeth takes on an unexpected position of power when the president's plane is declared missing; Henry's new handler asks him to recruit one of his students for the NSA.
Elizabeth confronts a former friend -- and remembers an important job offer from the past; Stevie and the president's son start a relationship.
Elizabeth discovers an assassination plot against the Iranian president, while dealing with a massive protest against Iran's plan to execute a gay citizen; in order to deal with her PTSD, Elizabeth sees a therapist.
A Russian nuclear submarine disappears in American waters, putting Elizabeth in a tricky situation; Stevie ends things with her boyfriend.
As President Dalton and Elizabeth try to solve the Greek debt crisis, not everyone is satisfied with the agreement; Henry considers a job offer; Stevie reconnects with a childhood friend.
While Elizabeth looks for a diplomatic way to handle a cult in Bolivia, the organization takes a congressman hostage; Stevie introduces her boyfriend to Elizabeth and Henry.
As Elizabeth attempts to hold herself together, she tries to prevent an ecological disaster and prepares for an appearance on "Face the Nation"; Henry and Elizabeth disagree on the level of protection Jason should have at school.
Elizabeth makes a secret trip to Iran in hope of preventing a coup that could affect President Dalton's administration; Elizabeth's staff is brought up to speed on the investigation into Marsh's death.
When the Turkish government releases a potentially damaging video, Elizabeth must mend political relations; Jason punches a school bully.
Elizabeth's staff fails to find existing corruption in her microloan program, leaving her humiliated at a public budget hearing; an investigation into Marsh's death progresses.
Elizabeth wants a Bahraini diplomat prosecuted when he is caught holding a maid hostage; Henry's father visits.
Elizabeth wants a Bahraini diplomat prosecuted when he is caught holding a maid hostage; Henry's father visits.
Elizabeth's wedding anniversary celebration is cut short when political tension forces her to re-examine an extradition deal she made; Elizabeth's son is injured while Blake is watching him.
As Elizabeth, Henry and Isabelle search for a secret bank account belonging to former Secretary of State Vincent Marsh, they learn that one of Elizabeth's staff members has access to it.
A deranged gunman puts the State Department on lockdown; a translator threatens to reveal damaging information about Elizabeth's time in the CIA; Matt reveals information to Daisy's fiance.
Elizabeth investigates a plane crash that killed Secretary of State Vincent Marsh; Nadine agrees to a date with a NASA scientist.
After being reactivated to the NSA, Henry lies about it to Elizabeth; the office is impacted by Daisy and Matt's antagonism.
Elizabeth brings Alison with her on a state department trip to India; when an earthquake causes an explosion at an American-owned factory, the chaos separates Elizabeth from her daughter.
Elizabeth asks the president for help with a dire situation in Western Africa but ends up being faced with unexpected consequences.
Elizabeth must negotiate with Iran regarding their escalating nuclear program; Jason interviews his father for a school report.
A Chinese student seeking political asylum threatens a potential peace treaty between Japan and China; tension grows between Stevie and Alison.
A hostile reporter threatens to publish confidential documents leaked from the State Department; Henry becomes involved in an international negotiation.
While Elizabeth deals with a crisis in Yemen, her eldest daughter makes headlines for protesting a new university policy.
Secretary of State Elizabeth McCord faces an abundance of political challenges, most importantly an international hostage situation; the McCord children struggle to adjust to their new schools.